PoQus (Portable Quantum Sensor for Time-Resolved Fluorescence Imaging) is a groundbreaking research project aimed at transforming image-guided surgery. By leveraging quantum sensing technology, we are developing an innovative portable fluorescence imaging system that will enable real-time, high-resolution tumor detection during surgery. This will enhance surgical precision, minimize the removal of healthy tissue, and improve patient outcomes.
At the heart of PoQus is a compact, energy-efficient cryogenic system powering state-of-the-art superconducting nanowire single-photon detectors (SNSPDs). These detectors offer unparalleled sensitivity, speed, and depth penetration, overcoming current limitations in optical imaging for medical diagnostics.
Using the SNSDPs as a basis, we want to develop a portable quantum sensor that is integrated into a time-resolved fluorescence microscope for use in operating rooms. The prototype will consist of a compact cryogenic cooling system, optimized detectors for maximum efficiency and speed, and software for image analysis,” says Oliver Bruns, outlining the plan.
Traditional imaging techniques struggle to provide real-time, high-resolution visualization of deep tissue structures, limiting a surgeon’s ability to accurately differentiate between healthy and cancerous tissue. PoQus aims to bridge this gap by integrating quantum-enhanced fluorescence lifetime imaging microscopy (FLIM) into a clinically viable system.
Through cutting-edge research, interdisciplinary collaboration, and clinical validation, PoQus will set the stage for a new era of quantum-assisted medical imaging, bringing breakthroughs in cancer detection and precision surgery to hospitals and operating rooms across Europe.
The EU provides funding for research and innovation, particularly through the Horizon Europe program. PoQus is part of a funding line that only supports collaborative projects known as ‘Global Challenges and European Industrial Competitiveness,’ in Cluster 4: Digital, Industry and Space. PoQus will receive a total of EUR 4,986,529 in funding, with almost EUR 1.1 million going to the Faculty of Medicine at TU Dresden and around EUR 1.2 million to the German Cancer Research Center (DKFZ). This money also benefits the Dresden site through the DKFZ’s financing of Oliver Brun’s Chair at TUD’s Faculty of Medicine.
